Pathological Mechanism of Mechanosensitive Cells Driving the Growth of Keloids

Keloids are overgrown scars that often cause chronic pain, itching, and restricted movement, but their biological origins remain unclear. In a recent study, researchers from Japan discovered a distinct subset of fibroblasts that senses mechanical tension through a protein called PIEZO2. These cells drive abnormal extracellular matrix collagen production and lead to scar recurrence, highlighting a potential therapeutic target and opening new avenues for the diagnosis and treatment of keloids.