High-Fat Diet Impairs Memory Formation by Reducing Autophagy

Increased consumption of high-fat foods has been linked to cognitive decline. The underlying mechanisms, however, remain unclear. A new study by researchers from Chiba University, Japan, finds that a high-fat diet (HFD) impairs intermediate-term memory formation in Drosophila by decreasing autophagic activity. Further, HFD-induced memory deficits can be reversed by enhancing autophagic activity, opening avenues for the development of preventive treatments and autophagy-promoting lifestyle interventions to preserve cognitive function.