How an Immune Cell Receptor Dampens the Fight Against Fungal Infection
2025.09.11
Research
People are constantly exposed to fungal spores, including those of Aspergillus fumigatus, but individuals with weakened immune systems may develop life-threatening infections. In a recent study, researchers from Japan clarified the mechanisms by which the dendritic cell immunoreceptor (Dcir) suppresses neutrophil activity during infection with A. fumigatus. Their findings highlight Dcir as a potential therapeutic target for aspergillosis and suggest promising research avenues in the field of immunology.
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Dcir recognizes Aspergillus fumigatus hyphae and dampens the degranulatory activity of neutrophils. Without Dcir, neutrophils show enhanced fungicidal activity, and the host’s ability to eliminate the pathogen is improved.